Job offer

PhD student Position: job filled

Project: Developments for the diagnosis of Alzheimer’s disease

At: Research Unit CRRET (Croissance, Réparation et Régénération Tissulaires)

University Paris-Est (UPEC), Créteil, France

https://www.vjf.cnrs.fr/spip/crret/

http://www.u-pec.fr/

The UPEC University in Paris area (based at 15 min from indoor Paris), is an internationally recognized research and learning center distinguished by the EU Commission with the Excellence in Science Award.

The laboratory CRRET/ERL CNRS 9215 (CRRET) at UPEC is a research unit dedicated to study the mechanisms regulating cell behavior during tissue regeneration and degeneration. The unit works to better understand the biological roles of glycosaminoglycans, particularly of heparan sulfates (HS), in the maintain or loss of tissue homeostasis. Under this context, the CRRET team developed a new glycobiology-related concept aiming to better understand the mechanisms leading to Alzheimer’s disease (AD). Recently, the team and its international consortium got the highest evaluation score under the European H2020 FET OPEN RIA Programs for its ArrestAD project, which develops an original diagnostic/therapeutic strategy based in a completely new vision of AD (https://arrestad.wordpress.com).

In the context, we search for an outstanding PhD student candidate to conduct innovative studies in the frame of the diagnosis branch of the ArrestAD project. The candidate will work in the development of a diagnostic kit-prototype for AD. In this context, the PhD selected student will have the opportunity to collaborate with internationally recognized experts in AD clinics and research and will participate in international scientific training programs and conferences.

The PhD student position, funded by a CIFRE agreement with PME, is planned to start in September or October 2018.

Requirements for PhD student candidates are:

  • Master degree in biochemistry, cell biology, neurosciences or related disciplines.
  • Strong interest in the molecular mechanisms of AD pathology and in glycosaminoglycans.
  • Proficiency in cell biology and associated technologies if possible in primary cell culture, confocal microscopy, and immunoblotting.
  • Knowledge in materials science as well as in the field of chemical surface modifications could be an asset for the application.
  • Exceptional motivation for scientific research.
  • Good written and oral communication and presentation skills.
  • Ability to work both independently as well as in a collaborative team.
  • Willingness to learn new technologies.
  • Fluency in French; knowledge of English is a plus but is not required.

Admission
The application should contain the following documents/information:

  • CV
  • Letter of intent (the letter should explain how your skills and interests overlap with the project goals, what you hope to gain from working with us and what you think you might uniquely bring to our team).
  • 2 letters of reference.
  • Copy of diploma.
  • Contact information, including e-mail address and phone number.

The candidates may include additional information or copies of documents/certificates in support of the application.

For information and application please contact

  • ArrestAD project coordinator:

Dr. Gael Le Douaron: gael.le-douaron@u-pec.fr

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Post Doctoral Research Position: job filled

Project: Heparan sulfates biology and Alzheimer’s disease

At: Research Unit CRRET (Croissance, Réparation et Régénération Tissulaires)

University Paris-Est (UPEC), Créteil, France

https://www.vjf.cnrs.fr/spip/crret/

http://www.u-pec.fr/

The UPEC University in Paris area (based at 15 min from indoor Paris), is an internationally recognized research and learning center distinguished by the EU Commission with the Excellence in Science Award.

The laboratory CRRET/ERL CNRS 9215 (CRRET) at UPEC is a research unit dedicated to study the mechanisms regulating cell behavior during tissue regeneration and degeneration. The unit is interested in understanding the biological roles of glycosaminoglycans, particularly of heparan sulfates (HS), in the maintain or the loss of tissue homeostasis. The CRRET team developed a new glycobiology-based concept allowing a better understanding of the mechanisms leading to Alzheimer’s disease (AD). Recently, the team got the highest evaluation score under the European H2020 FET OPEN Program for the ArrestAD project, which gives a radically new vision of AD with important diagnosis/therapeutic applications.

We search for an outstanding postdoctoral candidate to conduct innovative studies in the frame of the research project ArrestAD. The candidate will integrate this project with the responsibility of a mechanistic task aiming to study the processess involved in the traffic of HS under physiologic and pathologic conditions (cell lines, primary cultures of neuronal cells and in vivo). The candidate will have the opportunity to collaborate in the frame of the ArrestAD consortium with internationally recognized experts in AD clinics and research, and will participate in international scientific training programs and conferences.

The postdoctoral position is planned for Three years (2018 – 2020) with the possibility for the candidate to apply to a permanent national researcher position (“chargé de recherche CNRS”).

Requirements for postdoctoral candidates are:

  • PhD degree in biochemistry, cell biology, neurosciences or related disciplines.
  • Strong publication record in high impact factor (IF>10 in first or last position).
  • Strong interest in the molecular mechanisms of AD pathology and in glycosaminoglycans.
  • Proven proficiency in cell biology and associated technologies including confocal microscopy, transfection, flow cytometry, immunoblotting, rodent experiment, transcriptomic and/or other omics analysis preferred.
  • Exceptional motivation for scientific research especially in mechanistic studies.
  • Excellent written and oral communication and presentation skills.
  • Ability to work independently as well as in a collaborative team.
  • Willingness to learn new technologies.
  • Experience in PhD student training and authorization to conduct research (HDR) for candidate > 35 years old.
  • Experience in fundraising writing and obtaining as principal investigator for candidate > 35 years old.
  • Fluency in English; knowledge of French is a plus, but is not required.

Admission
The application should contain the following documents/information:

  • CV.
  • Letter of intent (the letter should explain how your skills and interests overlap with the project goals, what you hope to gain from working with us and what you think you might uniquely bring to our team).
  • 2 letters of reference.
  • Copy of PhD diploma.
  • Contact information, including e-mail address and phone number.

The candidates may include additional information or copies of documents/certificates in support of the application.

For information and application please contact

  • ArrestAD project coordinator:

Dr. Gael Le Douaron: g.ledouaron@gmail.com

  • Copy to the Laboratory Head:

Pr. Dulce PAPY-GARCIA: papy@u-pec.fr

 

 

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